SportsLine's model simulated Los Angeles Rams vs. San Francisco 49ers 10,000 times and made its Week 3 NFL picks, predictions and best bets

The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday’s game against the Los Angeles Rams.

In Week 3, the NFL 2024 season continues with many franchises struggling with injuries and potential doubts for Sunday's game. The New York Jets defeated the New England Patriots 23-3, marking the first game in Week 3.

San Francisco 49ers star tight end George Kittle is doubtful for Sunday's game at the Los Angeles Rams due to a hamstring injury. Kittle missed a second straight day of

San Francisco 49ers' George Kittle is listed as doubtful for Sunday's game against the Rams. He joins Christian McCaffrey and Deebo Samuel on the 49ers injury report

Injuries are piling up for the 49ers as they gear up for a critical showdown against the Rams. Head coach Kyle Shanahan provided insights into Kittle's situation, revealing that the tight end felt soreness after practice and was subsequently rested to manage his condition.

George Kittle could have to miss his first game of the season as the San Francisco 49ers take on the Los Angeles Rams on Sunday. Per ESPN's Adam

There may not be two teams more injured than the Los Angeles Rams and San Francisco 49ers, which will have a big impact on Sunday’s game at SoFi Stadium. The 49ers are missing Christian McCaffrey, Deebo Samuel and possibly George Kittle,

The San Francisco 49ers (1-1) visit the Los Angeles Rams (0-2) on Sunday, September 22, 2024 in matchup between NFC West rivals at SoFi Stadium. The Rams are listed as 6.5-point underdogs. For

What to look for from the top 49ers and Rams players and how to watch the game as they face off on Sunday, week 3.